Cryoglobulinemia Mixed- Symptoms, Causes, Treatment and Home Remedies

What is Cryoglobulinemia Mixed?

Cryoglobulinemia Mixed is a combination of Types II and III cryoglobulinemia. Mixed cryoglobulinemia represent 80% of all cryoglobulins. It is related with chronic inflammatory states such as systemic lupus erythematosus (SLE), Sjögren syndrome, and viral infections. It is rheumatoid factors of antibodies that bind to the Fc fragment of IgG. Mixed cryoglobulinemia present as vasculitis, recurrentlower extremity purpura, glomerulonephritis, and peripheral neuropathy. It causes due to the Hipatitis C.

Causes of Cryoglobulinemia Mixed

• Lymphoproliferative disorders.
• Liver diseases.
• Hepatitis C infection.
• Organ damage.
• Abnormal proteins.

What are the symptoms of Cryoglobulinemia Mixed?

• Skin manifestations.
• Blanching, pain, numbness in fingers and toes.
• Nervous system manifestations.
• Swelling of ankles and legs.
• Joint ache.
• Weakness.

Cryoglobulinemia MixedTreatment

• Nonsteroidal anti-inflammatory drugs (NSAIDs)
  1. Aspirin
  2. Naproxen
• Immunosuppressive drugs (Cytoxan®)
• Prednisone and cytotoxic drugs.
• Interferon-alpha.
• Plasmapheresis.
• Interferon alfa-2b.
• Mild cases can be treated by avoiding cold temperatures.
• Manifested by progressive renal failure, distal necroses requiring amputation, or advanced neuropathy.